Isthmin inhibits glioma growth through antiangiogenesis in vivo
نویسندگان
چکیده
منابع مشابه
Growth in Vivo Antisense-Vascular Endothelial Growth Factor Inhibits Tumor Antiangiogenesis Treatment for Gliomas
Presently, there is no effective treatment for glioblastoma, the most malignant and common brain tumor. Angiogenic factors are potentially optimal targets for therapeutic strategies because they are essential for tumor growth and progression. In this study, we sought a strategy for efficiently delivering an antisense cDNA molecule of the vascular endothelial growth factor (VEGF) to glioma cells...
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Presently, there is no effective treatment for glioblastoma, the most malignant and common brain tumor. Angiogenic factors are potentially optimal targets for therapeutic strategies because they are essential for tumor growth and progression. In this study, we sought a strategy for efficiently delivering an antisense cDNA molecule of the vascular endothelial growth factor (VEGF) to glioma cells...
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Angiogenesis is a critical physiologic process that is appropriated during tumorigenesis. Little is known about how this process is specifically regulated in the brain. Brain angiogenesis inhibitor-1 (BAI1) is a brain-predominant seven-transmembrane protein that contains five antiangiogenic thrombospondin type-1 repeats (TSR). We recently showed that BAI1 is cleaved at a conserved proteolytic c...
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متن کاملIsthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice
Anti-angiogenesis represents a promising therapeutic strategy for the treatment of various malignancies. Isthmin (ISM) is a gene highly expressed in the isthmus of the midbrain-hindbrain organizer in Xenopus with no known functions. It encodes a secreted 60 kD protein containing a thrombospondin type 1 repeat domain in the central region and an adhesion-associated domain in MUC4 and other prote...
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ژورنال
عنوان ژورنال: Journal of Neuro-Oncology
سال: 2012
ISSN: 0167-594X,1573-7373
DOI: 10.1007/s11060-012-0910-8